Cosmetic Compositions

ABSTRACT

A cosmetic composition comprises a) an N-acyl amino acid compound selected from the group consisting of N-acyl amino acid, its isomers, its salts, derivatives thereof, and mixtures thereof, and b) hexyldecanol.

CROSS REFERENCE TO RELATED APPLICATION(S)

This application claims the benefit of U.S. Provisional Application No.61/415,019, filed on Nov. 18, 2010.

FIELD OF THE INVENTION

The present invention relates to cosmetic composition containing anN-acyl amino acid compound, and preparation methods thereof. Suchcompositions are useful for regulating the condition of mammaliankeratinous tissue needing such treatments.

BACKGROUND OF THE INVENTION

Mammalian keratinous tissue, particularly human skin, is subjected to avariety of insults by both extrinsic and intrinsic factors. Suchextrinsic factors include ultraviolet radiation, environmentalpollution, wind, heat, infrared radiation, low humidity, harshsurfactants, abrasives, etc. Intrinsic factors, on the other hand,include chronological aging and other biochemical changes from withinthe skin. Whether extrinsic or intrinsic, these factors result invisible signs of skin damage. Typical skin damage in aging or damagedskin include fine lines, wrinkling, hyperpigmentation, sallowness,sagging, dark under-eye circles, puffy eyes, enlarged pores, diminishedrate of turnover, and abnormal desquamation or exfoliation. Additionaldamage incurred as a result of both external and internal factorsincludes visible dead skin i.e., flaking, scaling, dryness, androughness.

Currently, there are a number of personal care products that areavailable to consumers, which are directed toward improving the healthand physical appearance of keratinous tissues such as the skin, hair,and nails. The majority of these products are directed to delaying,minimizing or even eliminating skin wrinkling, spots, and otherhistological changes typically associated with the aging of skin orenvironmental damage to human skin. Consumers prefer topically appliedproducts since they are not only effective, but also safe and pleasantto use.

An N-acyl amino acid, particularly N-acyl derivatives of phenylalanineor tyrosine, their isomers, or their salts are known for being useful inpreventing or treating various ketatinization disorders. These compoundsare cosmetic active agents of choice such as for whitening products.

However, it has been observed that these compounds are difficult todissolve in cosmetic compositions, and these active agents have atendency to recrystallize. Oil compounds such as Eldew SL-205 fromAjinomoto, and octyldodecanol are known as an solvent for N-acyl aminoacid compounds.

Based on the foregoing, there is a continuing need to formulate cosmeticcompositions containing an N-acyl amino acid compound that can providestable delivery of skin actives.

SUMMARY OF THE INVENTION

The present invention relates to a cosmetic composition comprising a) anN-acyl amino acid compound selected from the group consisting of N-acylamino acid, its isomers, its salts, derivatives thereof, and mixturesthereof, and b) hexyldecanol.

The present invention also relates to methods of using such compositionsto regulate the condition of skin, said method comprising applying tothe skin of a human in need of treatment.

The present invention also relates to a method of preparing a cosmeticcomposition comprising, dispersing a first oil phase comprising anN-acyl amino acid compound and hexyldecanol in a continuous aqueousphase; and dispersing a second oil phase in the continuous aqueousphase.

These and other features, aspects, and advantages of the presentinvention will become evident to those skilled in the art from a readingof the present disclosure.

DETAILED DESCRIPTION OF THE INVENTION

While the specification concludes with the claims particularly pointingand distinctly claiming the invention, it is believed that the presentinvention will be better understood from the following description.

As used herein, the “cosmetic compositions” are those used to treat orcare for, or somehow moisturize, improve, clean the skin, or modifyappearance of skin, and include both skin care compositions and colorcosmetic compositions. Products contemplated by the phrase “skin careproducts” comprise, but are not limited to moisturizers, personalcleansing products, occlusive drug delivery patches, nail polish,powders, wipes, hair conditioners, skin treatment emulsions, shavingcreams, foundations and the like.

The compositions of the present invention can include, consistessentially of, or consist of, the components of the present inventionas well as other ingredients described herein.

The term “keratinous tissue” as used herein, refers tokeratin-containing layers disposed as the outermost protective coveringof mammals (e.g., humans, dogs, cats, etc.) which includes, but is notlimited to, skin, lips, hair, toenails, fingernails, cuticles, hooves,etc.

The term “safe and effective amount” as used herein, refers to an amountof a compound or composition sufficient to significantly induce apositive benefit, preferably a positive keratinous tissue appearance orfeel benefit, or positive hair appearance or feel benefit, includingindependently or in combinations the benefits disclosed herein, but lowenough to avoid serious side effects, i.e., to provide a reasonablebenefit to risk ratio, within the scope of sound judgment of the skilledartisan.

The term “regulating skin condition” as used herein, refers to improvingskin appearance and/or feel, for example, by providing a benefit, suchas a smoother appearance and/or feel. The benefit may be a chronicbenefit and may include one or more of the following: Reducing theappearance of wrinkles and coarse deep lines, fine lines, crevices,bumps, and large pores; thickening of keratinous tissue (e.g., buildingthe epidermis and/or dermis and/or sub-dermal layers of the skin, andwhere applicable the keratinous layers of the nail and hair shaft, toreduce skin, hair, or nail atrophy); increasing the convolution of thedermal-epidermal border (also known as the rete ridges); preventing lossof skin or hair elasticity, for example, due to loss, damage and/orinactivation of functional skin elastin, resulting in such conditions aselastosis, sagging, loss of skin or hair recoil from deformation;reduction in cellulite; change in coloration to the skin, hair, ornails, for example, under-eye circles, blotchiness (e.g., uneven redcoloration due to, for example, rosacea), sallowness, discolorationcaused by hyperpigmentation, etc.

All percentages, parts and ratios are based upon the total weight of thecompositions of the present invention and all measurements made are at25° C., unless otherwise designated. All such weights as they pertain tolisted ingredients are based on the active level and, therefore, do notinclude carriers or by-products that may be included in commerciallyavailable materials, unless otherwise specified.

The compositions of the present invention are useful for regulating thecondition of skin and especially for regulating keratinous tissuecondition.

The compositions of the present invention provide additional benefits,including stability, absence of significant (consumer-unacceptable) skinirritation and good aesthetics.

The compositions of the present invention optionally comprise anemulsifier, a skin active, a skin conditioning agent, a sunscreen agent,a thickening agent, and a non-emulsifying crosslinked siloxaneelastomer.

The compositions of the present invention optionally comprise additionaloil which can solubilize an N-acyl amino acid compound.

The compositions of the present invention are described in detailhereinafter.

N-Acyl Amino Acid Compound

The compositions of the present invention comprise a safe and effectiveamount of one or more N-acyl amino acid compounds. The amino acid can beone of any of the amino acids known in the art. The N-acyl amino acidcompounds of the present invention correspond to the formula:

wherein R can be a hydrogen, alkyl (substituted or unsubstituted,branched or straight chain), or a combination of alkyl and aromaticgroups. A list of possible side chains of amino acids known in the artare described in Stryer, Biochemistry, 1981, published by W.H. Freemanand Company. R¹ can be C₁ to C₃₀, saturated or unsaturated, straight orbranched, substituted or unsubstituted alkyls; substituted orunsubstituted aromatic groups; or mixtures thereof.

Preferably, the N-acyl amino acid compound is selected from the groupconsisting of N-acyl Phenylalanine, N-acyl Tyrosine, their isomers,their salts, derivatives thereof, and mixtures thereof. The amino acidcan be the D or L isomer or a mixture thereof. N-acyl Phenylalaninecorresponds to the following formula:

wherein R¹ can be C₁ to C₃₀, saturated or unsaturated, straight orbranched, substituted or unsubstituted alkyls; substituted orunsubstituted aromatic groups; or mixtures thereof.

N-acyl Tyrosine corresponds to the following formula:

wherein R¹ can be C₁ to C₃₀, saturated or unsaturated, straight orbranched, substituted or unsubstituted alkyls; substituted orunsubstituted aromatic groups; or mixtures thereof.

Particularly useful as a topical skin tone evening (lightening orpigmentation reduction) cosmetic agent isN-undecylenoyl-L-phenylalanine. This agent belongs to the broad class ofN-acyl Phenylalanine derivatives, with its acyl group being a C11mono-unsaturated fatty acid moiety and the amino acid being the L-isomerof phenylalanine. N-undecylenoyl-L-phenylalanine corresponds to thefollowing formula:

As used herein, N-undecylenoyl-L-phenylalanine is commercially availableunder the tradename Sepiwhite® from SEPPIC.

The compositions according to the present invention comprise the N-acylamino acid from about 0.001% to about 10%, preferably from about 0.01 toabout 5%, and more preferably from about 0.1% to about 4% by weight ofthe composition.

Hexyldecanol

The compositions of the present invention comprise hexyldecanol.

The compositions according to the present invention comprisehexyldecanol preferably from about 0.004% to about 50%, more preferablyfrom about 0.04% to about 30%, and more preferably from about 0.4% toabout 20% by weight of the composition. The amount of hexyldecanol inthe compositions of the present invention can be easily determined uponthe amount of an N-acyl amino acid compound and/or the presence of anadditional solvent and/or a co-solvent for the N-acyl amino acidcompound. Without an additional solvent and a co-solvent, in thecompositions of the present invention, the ratio of hexyldecanol to anN-acyl amino acid is preferably no less than 4, and more preferably noless than 5.

Optional Components Water

The cosmetic compositions of the present invention may comprise waterpreferably from 10% to 90%, more preferably from about 30% to 80% andmore preferably from 40% to 60% by weight of the composition.

Emulsifiers

The composition of the present invention may contain an emulsifier,useful for dispersing and suspending a discontinuous phases in acontinuous phase when a product is in an emulsion type. An emulsifier inthe present invention can be selected from the group consisting ofnonionic emulsifiers, anionic emulsifiers, cationic emulsifiers,amphoteric emulsifiers, and mixtures thereof. When the composition ofthe present invention contains an emulsifier, in a preferred embodiment,the composition contains from about 0.1% to about 10% emulsifier, morepreferably from about 0.2% to about 7.5%, even more preferably fromabout 0.5% to about 5%, emulsifier by weight of the composition. A widevariety of emulsifying agents can be employed herein.

In one embodiment, non-limiting examples of which include non-ionic andanionic emulsifying agents such as sugar esters and polyesters,alkoxylated sugar esters and polyesters, C₁-C₃₀ fatty acid esters ofC₁-C₃₀ fatty alcohols, alkoxylated derivatives of C₁-C₃₀ fatty acidesters of C₁-C₃₀ fatty alcohols, alkoxylated ethers of C₁-C₃₀ fattyalcohols, polyglyceryl esters of C₁-C₃₀ fatty acids, C₁-C₃₀ esters ofpolyols, C₁-C₃₀ ethers of polyols, alkyl phosphates, polyoxyalkylenefatty ether phosphates, fatty acid amides, acyl lactylates, soaps, andmixtures thereof. Nonlimiting examples of other emulsifiers for useherein include: polyethylene glycol 20 sorbitan monolaurate (polysorbate20), steareth-20, ceteareth-20, PPG-2 methyl glucose ether distearate,ceteth-10, polysorbate 80, cetyl phosphate, potassium cetyl phosphate,diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate,PEG-100 stearate, polyoxyethylene 20 sorbitan trioleate (polysorbate85), sorbitan monolaurate, polyoxyethylene 4 lauryl ether sodiumstearate, polyglyceryl-4 isostearate, hexyl laurate, PPG-2 methylglucose ether distearate, ceteth-10, diethanolamine cetyl phosphate,glyceryl stearate, PEG 40 hydrogenated castor oil, PEG-60 hydrogenatedcastor oil, Glycereth-25 PCA Isostearate, and mixtures thereof.

Another preferred emulsifier herein is cationic emulsifiers.Non-limiting examples of cationic emulsifiers include quaternaryammonium salts or amido-amines having at least one fatty chaincontaining at least about 8 carbon atoms and mixtures thereof.

Another preferred emulsifier herein is amphoteric emulsifiers.Non-limiting example of amphoteric emulsifiers includesphosphatidylcholine, hydrogenated phosphatidylcholine, lecithin,hydrogenated lecithin, hydroxylated lecithin, lysoletcithin and mixturesthereof.

Another preferred emulsifier herein is silicone emulsifiers, includingorganically modified organopolysiloxanes such as dimethicone copolyols.

Skin Actives

The compositions of the present invention may include at least one skinactive compound. Without being bound by theory, it is believed thepresent compositions provide versatility in formulating a variety ofactives.

In any embodiment of the present invention, however, the actives usefulherein can be categorized by the benefit they provide or by theirpostulated mode of action. However, it is to be understood that theactives useful herein can in some instances provide more than onebenefit or operate via more than one mode of action. Therefore,classifications herein are made for the sake of convenience and are notintended to limit the active to that particular application orapplications listed.

Vitamin B₃ Compounds

Vitamin B₃ compounds such as niacinamide are a preferred skin careactive for use herein. The present invention preferably includes fromabout 0.1% to about 30%, more preferably from about 1% to about 20%,even more preferably from about 2% to about 10% of a vitamin B₃compound.

As used herein, “vitamin B₃ compound” means a compound having theformula:

wherein R is —CONH₂ (i.e., niacinamide), —COOH (i.e., nicotinic acid) or—CH₂OH (i.e., nicotinyl alcohol); derivatives thereof; and salts of anyof the foregoing. Exemplary derivatives of the foregoing vitamin B₃compounds include nicotinic acid esters, including non-vasodilatingesters of nicotinic acid (e.g., tocopheryl nicotinate), nicotinyl aminoacids, nicotinyl alcohol esters of carboxylic acids, nicotinic acidN-oxide and niacinamide N-oxide.

Whitening Agents

The present compositions may contain a whitening agent. The whiteningagent useful herein refers to active ingredients that not only alter theappearance of the skin, but further improve hyperpigmentation ascompared to pre-treatment. Useful whitening agents useful herein includeascorbic acid compounds, vitamin B₃ compounds, azelaic acid, butylhydroxy anisole, gallic acid and its derivatives, hydroquinoine, kojicacid, arbutin, mulberry extract, tetrahydrocurcumin, and mixturesthereof. Use of combinations of whitening agents is also believed to beadvantageous in that they may provide whitening benefit throughdifferent mechanisms.

When used, the compositions preferably contain from about 0.1% to about10%, more preferably from about 0.2% to about 5%, by weight of thecomposition, of a whitening agent.

Ascorbic acid compounds are useful whitening agents, and includecompounds having the formula (I):

wherein V and W are independently —H or —OH; R¹ is —CH(OH)—CH₂OH; saltsthereof; and derivatives thereof. Preferably, the ascorbic acid compounduseful herein is an ascorbic acid salt or derivative thereof, such asthe non-toxic alkali metal, alkaline earth metal and ammonium saltscommonly known by those skilled in the art including, but not limitedto, the sodium, potassium, lithium, calcium, magnesium, barium, ammoniumand protamine salts which are prepared by methods well known in the art.Ascorbyl glucoside is a preferably derivative.

Peptides

Peptides, including but not limited to, di-, tri-, tetra-, andpentapeptides and derivatives thereof, may be included in thecompositions of the present invention in amounts that are safe andeffective. As used herein, “peptides” refers to both the naturallyoccurring peptides and synthesized peptides. Also useful herein arenaturally occurring and commercially available compositions that containpeptides.

When included in the present compositions, peptides are preferablyincluded in amounts of from about 1×10⁻⁶% to about 10%, more preferablyfrom about 1×10⁻⁶% to about 0.1%, even more preferably from about1×10⁻⁵% to about 0.01%, by weight of the composition.

Sugar Amines

The compositions of the present invention may include a safe andeffective amount of a sugar amine, which are also known as amino sugars.As used herein, “sugar amine” refers to an amine derivative of asix-carbon sugar. Examples of sugar amines that are useful hereininclude glucosamine, N-acetyl glucosamine, mannosamine, N-acetylmannosamine, galactosamine, N-acetyl galactosamine. Preferred for useherein is glucosamine. Additionally, combinations of two or more sugaramines may be used.

When included in the present compositions, a sugar amine is preferablyincluded in amounts of from about 0.001% to about 20%, more preferablyfrom about 1% to about 10%, even more preferably from about 2% to about5%, by weight of the composition.

Skin Conditioning Agent

Optionally, the composition of the present invention can furthercomprise a skin conditioning agent. These agents may be selected fromhumectants, exfoliants or emollients. The amount of skin-condition agentmay range from about 1% to about 60%, preferably from about 2% to about50%, more preferably from about 5% to about 40%, by weight of thecomposition.

Humectants are polyhydric alcohols intended for moisturizing, reducingscaling and stimulating removal of built-up scale from the skin. Typicalpolyhydric alcohols include polyalkylene glycols and more preferablyalkylene polyols and their derivatives. Illustrative are propyleneglycol, dipropylene glycol, polypropylene glycol, polyethylene glycol,sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol,1,2,6-hexanetriol, ethoxylated glycerin, propoxylated glycerin andmixtures thereof. Most preferably the humectant is glycerin.

Exfoliants according to the present invention may be selected fromC2-C30 alpha-hydroxycarboxylic acids, beta-hydroxycarboxylic acids andsalts of these acids. Most preferred are glycolic, lactic and salicylicacids and their ammonium salts.

When the conditioning agent is an emollient it may be selected fromhydrocarbons, fatty acids, fatty alcohols and esters.

Sunscreen Agents

The compositions according to the present invention may optionallycontain a sunscreen agent selected from an organic sunscreen agent andan inorganic sunscreen agent.

Organic sunscreen agents useful herein include homosalate, octocrylene,octyl-p-methoxycinnamate, phenyl benzimidazole sulfonic acid,2-hydroxy-4-methoxybenzophenone (Benzophenone-3),2-ethylhexyl-salicylate, and mixtures thereof.

Inorganic sunscreen agents useful herein include the following metallicoxides; titanium dioxide, zinc oxide, zirconium oxide, iron oxide, andmixtures thereof.

When included in the present compositions, the sunscreens are preferablyincluded in amounts of from about 0.1% to about 20%, preferably fromabout 0.5% to about 10%, more preferably from about 1% to about 5%, byweight of the composition. Exact amounts will vary depending upon thesunscreen or sunscreens chosen and the desired Sun Protection Factor(SPF).

Thickening Agents

The compositions of the present invention, in some embodiments, mayfurther include one or more thickening agents.

Nonlimiting classes of thickening agents include those selected from thefollowing: carboxylic acid polymers, crosslinked polyacrylate polymers,polyacrylamide polymers, polysaccharides and gums.

When present, the composition preferably includes from about 0.01% toabout 5%, more preferably from about 0.1% to about 4%, and still morepreferably from about 0.1% to about 3%, by weight of the composition ofthe thickening agent.

Non-Emulsifying Crosslinked Siloxane Elastomers

The compositions of the present invention may optionally containnon-emulsifying crosslinked siloxane elastomers. The term“non-emulsifying crosslinked siloxane elastomers,” as used herein,defines crosslinked organopolysiloxane elastomer from whichpolyoxyalkylene units or polyglycerin units are absent.

Non-limiting examples of non-emulsifying crosslinked siloxane elastomersused herein include dimethicone/vinyl dimethicone crosspolymers,supplied by a variety of suppliers including Dow Corning™ (DC 9040 andDC 9041), General Electric™ (SFE 839), Shin-Etsu™ (KSG-15, 16, 18[dimethicone/phenyl vinyl dimethicone crosspolymer]), and GrantIndustries (GRANSIL™ line of elastomers). Cross-linked siloxaneelastomers useful in the present invention and processes for making themare further described in U.S. Pat. No. 4,970,252 to Sakuta, et al.; U.S.Pat. No. 5,760,116 to Kilgour, et al.; and U.S. Pat. No. 5,654,362 toSchulz, Jr., et al. issued Aug. 5, 1997. Additional crosslinkedorganopolysiloxane elastomers useful in the present invention aredisclosed in Japanese Patent Application JP 61-18708, assigned to PolaKasei Kogyo KK.

In some embodiments, the composition may contain from about 0.1% toabout 15%, preferably from about 0.1% to about 10%, most preferably fromabout 1% to about 6% of a non-emulsifying crosslinked siloxane elastomerby weight of the composition.

Other Optional Ingredients

A variety of additional ingredients can be incorporated into thecompositions of the present invention. Nonlimiting examples of theseadditional ingredients include; particular materials to modify skin feelor appearance; anti-acne actives; oil-soluble beta-hydroxy acids such assalicylic acid and derivatives thereof; chelators; flavonoid compounds;anti-inflammatory agents; anti-cellulite agents; desquamation actives;anti-oxidant/radical scavengers; tanning actives; skin soothing or skinhealing actives such as panthenoic acid derivatives (includingpanthenol, dexpanthenol, ethyl panthenol), aloe vera, allantoin,bisabolol, and dipotassium glycyrrhizinate; antimicrobial or antifungalactives.

Composition Preparation

The compositions according to the present invention are generallyprepared by conventional methods such as are known in the art of makingtopical compositions. Such methods typically involve mixing of theingredients in one or more steps to a relatively uniform state, with orwithout heating, cooling, application of vacuum, and the like.

Products for Topical Use

The topical compositions of the present invention may be formulated intoa facial skin cosmetic such as foundations, moisturizer, wrinklesoothing serum, lotion, skin facial mask, skin lotion, skin cream, skingel, eye gel, eye cream, or any other commonly known skin product ortreatment.

In some embodiments, the compositions according to the present inventionare in the form of water-in-oil emulsion and comprise an oil phasecomprising an N-acyl amino acid compound and hexyldecanol.

In some embodiments, the compositions according to the present inventionare in the form of oil-in-water emulsion and comprise an oil phasecomprising an N-acyl amino acid compound and hexyldecanol dispersed in acontinuous aqueous phase.

In some embodiments, the compositions according to the present inventionare in the form of oil-in-water emulsion comprising a first oil phasecomprising an N-acyl amino acid compound and hexyldecanol in acontinuous aqueous phase, and a second oil phase comprising anon-emulsifying crosslinked siloxane elastomer in the continuous aqueousphase.

Method of Use

Applicants have found that the compositions of the present invention areuseful in a variety of applications directed to enhancement of mammalianskin. The methods of use for the compositions disclosed and claimedherein include, but are not limited to: 1) methods of increasing thesubstantivity of a cosmetic to skin; 2) methods of moisturizing skin; 3)methods of improving the natural appearance of skin; 4) methods ofapplying a color cosmetic to skin; 5) methods of preventing, retarding,and/or treating wrinkles; 6) methods of providing UV protection to skin;7) methods of preventing, retarding, and/or controlling the appearanceof oil; 8) methods of modifying the feel and texture of skin; 9) methodsof providing even skin tone; 10) methods of preventing, retarding,and/or treating the appear of spider vessels and varicose veins; 11)methods of masking the appearance of vellus hair on skin; and 12)methods of concealing blemishes and/or imperfections in human skin,including acne, age spots, freckles, moles, scars, under eye circles,birth marks, post-inflammatory hyperpigmentation, etc. Each of themethods discussed herein involve topical application of the claimedcompositions to skin.

EXAMPLES

The following examples further describe and demonstrate embodimentswithin the scope of the present invention. The examples are given solelyfor the purpose of illustration and are not to be construed aslimitations of the present invention, as many variations thereof arepossible without departing from the spirit and scope of the invention.

Examples 1 and 2

N-undecylenoyl-L-phenylalanine 5 g was added to hexyldecanol 25 g and 40g, respectively, and the mixtures were heated at about 70-80° C. for 20min and cooled down to ambient temperature. After that, clarity of theobtained solutions was evaluated visually.

Obtained solutions had clear appearances. No formation of crystals wasobserved at the time of preparation of the solutions, or after 24 hoursat 25° C.

Examples 3-7

Oil-in-water emulsions are prepared by conventional methods from thefollowing components.

TABLE 1 Components (values in wt %) Ex. 3 Ex. 4 Ex. 5 Ex. 6 A. Oil phase1 Hexyldecanol 4.0 5.0 8.0 15.0  N-undecylenoyl-L-phenylalanine 0.4 1.01.0 2.5 Isohexadecane — — 1.0 — B. Oil phase 2 Dimethicone-6cs*¹ — — 2.0— Dow Corning 9040 Silicone Elastomer*² — — 4.0 2.0 KSG-15*³ — 5.0 — —KSG-16*⁴ — — — 3.0 C. Aqueous phase Carbopol Ultrez 20*⁵ — 0.3 0.3 0.5Polyacrylamide/C13-14 Isoparaffin/ 1.0 0.5 0.5 1.0 Laureth-7*⁶ Glycerin— 3.0 10.0  5.0 Phenoxylethanol 0.2 0.2 0.2 0.2 Niacinamide 5.0 4.0 3.02.0 1,2-Pentanediol 3.0 3.0 2.0 3.0 Sodium hydroxide adjust pH to6.0-7.0 Water qs to 100 *¹Dimethicone-6cs: KF-96A-6cs available fromShin-Etsu Chemical Co. Ltd. *²Dow Corning 9040 Silicone Elastomer*³KSG-15: available from Shin-Etsu Chemical Co. Ltd. *⁴KSG-16: availablefrom Shin-Etsu Chemical Co. Ltd. *⁵Carbopol Ultrez 20: available fromNoveon *⁶Polyacrylamide/C13-14 Isoparaffin/Laureth-7: Sepigel 305available from SEPPIC Inc.Compositions of Examples 3-7 are suitably made as follows:

-   (1) Phase A: All ingredients are mixed in a vessel using a suitable    mixer (e.g., Anchor blade, propeller blade or IKA T25) until the    phase become clear under heating at about 70-80° C.-   (2) Phase B: All ingredients are mixed in a vessel using a suitable    mixer (e.g., Anchor blade, propeller blade or IKA T25) until the    phase is homogenous.-   (3) Phase C: Disperse polymer powder or polymer thickener premix in    water, and neutralize it to target pH if necessary. Add other water    soluble ingredients and mix until the phase is homogenous. Solid    ingredients, if any, can be pre-dissolved in part of water and then    blend into the aqueous phase.-   (4) Slowly add Phase A into Phase C and mix until batch is    homogenous. For Examples 4-6, slowly add Phase B into the mixture of    Phase A and Phase C and mix until batch is homogenous.

Appearance of composition of Example 3 was evaluated visually. Noformation of crystals or precipitation was observed at the time ofpreparation of the composition, or after 5 days at 50° C.

It is understood that the foregoing detailed description of examples andembodiments of the present invention are given merely by way ofillustration, and that numerous modifications and variations may becomeapparent to those skilled in the art without departing from the spiritand scope of the invention; and such apparent modifications andvariations are to be included in the scope of the appended claims.

The dimensions and values disclosed herein are not to be understood asbeing strictly limited to the exact numerical values recited. Instead,unless otherwise specified, each such dimension is intended to mean boththe recited value and a functionally equivalent range surrounding thatvalue. For example, a dimension disclosed as “40 mm” is intended to mean“about 40 mm.”

Every document cited herein, including any cross referenced or relatedpatent or application is hereby incorporated herein by reference in itsentirety unless expressly excluded or otherwise limited. The citation ofany document is not an admission that it is prior art with respect toany invention disclosed or claimed herein or that it alone, or in anycombination with any other reference or references, teaches, suggests ordiscloses any such invention. Further, to the extent that any meaning ordefinition of a term in this document conflicts with any meaning ordefinition of the same term in a document incorporated by reference, themeaning or definition assigned to that term in this document shallgovern.

While particular embodiments of the present invention have beenillustrated and described, it would be obvious to those skilled in theart that various other changes and modifications can be made withoutdeparting from the spirit and scope of the invention. It is thereforeintended to cover in the appended claims all such changes andmodifications that are within the scope of this invention.

1. A cosmetic composition comprising: a) an N-acyl amino acid compound selected from the group consisting of N-acyl amino acid, its isomers, its salts, derivatives thereof, and mixtures thereof and b) hexyldecanol.
 2. A cosmetic composition of claim 1 wherein said N-acyl amino acid is selected from the group consisting of N-acyl phenylalanine, N-acyl tyrosine, their isomers, their salts, derivatives thereof, and mixtures thereof.
 3. A cosmetic composition of claim 2 wherein said N-acyl phenylalanine is N-undecylenoyl-L-phenylalanine.
 4. A cosmetic composition of claim 1 wherein said composition comprises said N-acyl amino acid compound in the range of from about 0.001% to about 10% by weight of the composition.
 5. A cosmetic composition of claim 1 wherein said composition comprises said hexyldecanol in the range of from about 0.004% to about 50% by weight of the composition.
 6. A cosmetic composition according to claim 1, wherein said composition further comprises a skin care active selected from the group consisting of vitamin B₃ compounds, whitening agents, peptides, sugar amines, and mixtures thereof.
 7. A cosmetic composition according to claim 6, wherein said skin care active is vitamin B₃ compounds.
 8. A cosmetic composition according to claim 1, wherein said composition further comprises sunscreen agents.
 9. A cosmetic composition according to claim 1, wherein said composition further comprises an additional solvent for said N-acyl amino acid compound.
 10. A cosmetic composition according to claim 1, wherein said composition is oil-in-water emulsion comprising an oil phase comprising said N-acyl amino acid compound and said hexyldecanol dispersed in a continuous aqueous phase.
 11. A cosmetic composition according to claim 10, wherein said composition further comprises a non-emulsifying crosslinked siloxane elastomer.
 12. A method of regulating the condition of skin, said method comprises applying to the skin of a human, a safe and effective amount of a cosmetic composition according to claim
 1. 13. A method of preparing a cosmetic composition comprising. dispersing a first oil phase comprising an N-acyl amino acid compound and hexyldecanol in a continuous aqueous phase; and dispersing a second oil phase in the continuous aqueous phase.
 14. A method according to claim 13, wherein said second oil phase comprises a non-emulsifying crosslinked siloxane elastomer. 